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Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11 (Liu Y

Cytokine-stimulated activated NK cells detach earlier than resting NK cells, correlating with their potent cytotoxicity

Regarding the measurement of the serum HO-1 change, HO-1 was significantly higher in only male ICF subjects (not total subjects) compared to the control group