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doi: 10.1038/s41467-019-13668-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 2

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Functionalized Nanoparticles Crossing the Brain-Blood Barrier to Target Glioma Cells

Therefore, patients should be advised to avoid exposing the application site to sources of direct heat, such as heating pads or electric blankets, heat lamps, saunas, hot tubs, heated water beds, and prolonged direct sunlight

Another problem is that these medicines need to be taken multiple times a day, and we know that adherence would go up dramatically if they were needed only once-a-day