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First, we culture our tendons under stress-deprivation rather than with a tensile static or cyclic load that would better mimic physiologic conditions

This is a very important question that could potentially be approached experimentally by using CD38 constructs targeted for different sub-cellular distributions and the newly developed NAD biosensors [80-81]

For instance, the cuproenzyme LOX is involved in the invasion and metastasis of tumor cells

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& Wirthensohn, G