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These preclinical findings align with a broader body of evidence supporting mechanism-based drug combinations to reduce required doses and potentially improve safety profiles ( The experimental model employedL5L6 spinal nerve ligationis a well-established paradigm that recapitulates key features of clinical neuropathic pain, including mechanical allodynia, and offers high predictive validity for therapeutic response ( First, while isobolographic analysis remains the reference standard for evaluating drug interactions, it does not delineate underlying mechanisms