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Observational studies in children indicate that the effects of high blood pressure begin well before adulthood.27 The prevalence of hypertension is approximately doubled in diabetic patients compared with non- diabetic controls.28,29 In T1DM, hypertension can be essential hypertension or related to diabetic kidney disease

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The model describes a positive feedback (more cytotoxicity releases more auto-antigens) and a negative one (cytotoxicity stimulates immunoregulatory T Reg )