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Its particularly during periods of rapid growth like pregnancy

Furthermore, IL-8 promotes the activation of mononuclear cell leukocytes into the synovium, degranulation of neutrophils, production of MMP-13 by chondrocytes, apoptosis of chondrocytes and loss of proteoglycans (2830)

Nature 427(6977):843848

These tyrosines create docking sites for a variety of adaptor proteins and direct kinase substrates including the growth factor receptor-bound protein 2 (Grb2), Grb2-associated adaptor protein (Gab1), son of sevenless (SOS), SRC homology protein tyrosine phosphatase 3 (Shp2), phosphatidylinositol-3-kinase (PI3K) and signal transducer and activator of transcription 3 (STAT3)

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