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This studys limitations refer to meta-data sets available for analysis, data type (e.g., microarrays), DM expression profile composition (cellular mixture), CR experimental time design, and pre-clinical models of CR effects on tumor pathobiology

However, the doses employed in those experiments were much higher than the standard IC 50 for rotenone

Nature Reviews Neuroscience

Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide