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Key findings on physical examination include weight loss, presence of a goitre (unilateral or bilateral palpable thyroid gland) and cardiac auscultation abnormalities such as tachycardia, new heart murmur and gallop rhythm ( Figure 1 )

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Data from nerve conduction velocities, sympathetic skin responses in the palms and soles, skin biopsies, and intraepidermal nerve fiber densities showed that neurotoxic treatment causes typical small fiber neuropathy with reduced intraepidermal nerve fiber density (IENFD) and reduced C-fiber conduction velocity

Congestive heart failure, like you stop being able to even walk down the hall of your own house, like there's a lot of sequelae that come out of that