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Indication: As an adjunct treatment to minimize the occurrence of toxicity associated with cisplatin chemotherapy

2007 Oct;125(10):1396-401

Despite the mitigating mortality and morbidity rates concomitant with the rapid evolution of medical technologies, the heart failure precipitated by MI continues to remain alarmingly high, imposing a substantial financial and societal burden on individuals and communities [393, 394]

Here's what happens: Just 200 mcg of folic acid overwhelms your DHFR enzyme Unmetabolized folic acid (UMFA) accumulates in your bloodstream UMFA competes with natural folate and blocks methylfolate from binding to FR Your brain's primary folate delivery system gets shut down For pregnancy: Folic acid blocks the FR receptor that delivers folate to both the placenta and your baby's developing brain