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Side effects are common and well-documented: nausea (85% of first-time users), facial flushing, fatigue, and injection site pain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 236.Maciejewski ML, Smith VA, Berkowitz TSZ, Arterburn DE, Mitchell JE, Olsen MK, Liu CF, Livingston EH, Funk LM, Adeyemo A, Bradley KA

Fourteen of the 16 patients (87.5%) reported significant pain relief

Interestingly, low blood levels of vitamin B12 have been linked with reduced bone mass, though clinical trials have not definitively supported the efficacy of B vitamin supplements in treating fractures ( Recent research states that the role of vitamin B12 and bone health is not well established