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doi: 10.3389/fimmu.2020.583687 59 FragaM

Long-term safety data doesn't exist for either component

Many peptides used in medicine are compounded formulations, meaning they are customized rather than commercially approved drugs. While semaglutide is FDA-approved, not all peptides produced at compounding pharmacies are

The standard tirzepatide protocol follows a gradual increase designed to minimize gastrointestinal side effects while reaching therapeutic doses

The FDA has not approved them for medical treatment
