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These results suggested that PXR promoted cell viability and conferred IR resistance through facilitating ATM activation of DNA damage response and repair in liver and colon cancer cells

The conclusion of the study stated "Thus, the vitamin D supplements widely consumed by the public are unlikely to be successful unless the GSH (glutathione) status is also corrected." Other 2019 findings confirmed that high fat diets induced fatty liver, which reduced glutathione levels in the liver

A high percentage of phytochemicals have low solubility, high first-pass metabolism, and extensive first-pass degradation resulting in low plasma concentrations, which are much lower than those needed to achieve biological effects in vitro [328, 348]

Pathol Int 2009;59:7-18