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Description
The 2-oxoacid dehydrogenase complexes in mitochondria can produce Superoxide/Hydrogen peroxide at much higher rates than complex I

Sikiric et al., 1999b

& Shoenfeld, Y

271 MitoROS serve as physiological AMPK activators, with AMPK activation triggering a PGC-1-dependent antioxidant response that limits mitoROS production