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E.YinP.WeiJ.ZuberiA.IizukaT.SuzukiT.et al (2025)

In turn, bacteria release short-chain fatty acids (SCFAs) that are beneficial for the host (2931)

Similar concerns apply to phosphodiesterase-5 inhibitors (medications like sildenafil) and L-arginine supplements that also influence nitric oxide signaling
The threshold at which this association has been observed is serum levels over 813 pg/mL (600 pmol/L)

Pathophysiology Excessive breakdown of heme occurs due to hemolysis, which can be caused by various hereditary and autoimmune diseases that result in deficient red blood cell membranes (such as hereditary spherocytosis), enzyme deficiencies (such asG6PD), and abnormalities in hemoglobin structure
