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The interactions between NNMT and three methionine cycle-related proteins AHCY, BHMT, and MAT1A were validated through Co-IP followed by immunoblotting in mouse liver and 293 T cells [40]

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Furthermore, the study hypothesizes a potential interaction of AOD9604 with the beta-adrenergic pathway, especially concerning the beta(3)-adrenergic receptors (beta(3)-AR), which are considered to be key lipolytic receptors found in fat cells

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