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such dysfunction requires etiologic evaluation and targeted treatment rather than calendar-based timing adjustment [287, 289, 290]

Understanding that this change is typically a precursor to further deterioration is important for timely intervention

An alternative interpretation for the first phase could be a rapid noncovalent interaction between PfGrx and GSSG in the vicinity of roGFP2, however, this seems less likely considering the smaller values for the structurally similar PfGrx mutants or, in particular, the rxYFP fusion constructs with ScGrx1 (Table 1)

doi: 10.1016/j.jad.2022.01.038

Peptides were assigned to TfR1 comes based on localization probability, which is generally considered good at a value of 0.75 or higher