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Investigations of oxidative PTMs (ox-PTMs) that occur in vitro or in vivo are currently being performed with focused redox proteomics techniques (299301)

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Navarro-Martn et al

65,66 Since we still do not totally understand the pathophysiology of COPD development, and patients applied current drugs may acquire resistance or side effect, there is an urgent unmet need to identify other critical therapeutic targets or medicine for this disease

These findings demonstrate that UA treatment provokes the antioxidant system in macrophages leading to increased expression of the enzymes involved in the so-called glutathione system