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10.1016/j.taap.2016.12.005 115 KizubI

These activated subunits bind to flavocytochrome and induce the synthesis of radical species such as O 2 and OH [87]

Although it is considered that the production of sulfates and glucuronides aims to facilitate the excretion of xenobiotics in the urine, their hydrophilicity allows the transport of these metabolites through the blood, reaching various tissues where they can later be deconjugated by enzymes such as -glucuronidases or sulfatases

General Oxidative Stress Reactive Oxygen Species (ROS) include both free radicals and non-free-radical oxygen intermediates which are generated endogenously