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The mobile phase consisted of water (A) with 0.1% v/v formic acid and methanol (B) with 0.1% v/v formic acid

66 Consequently, BrtA exposure to cholic acids inhibits BrtA binding to the promoter of the multi-drug efflux pump mdrT , inducing MdrT expression and allowing the export of cholic acids

Clinically isolated syndrome (CIS) A first attack of neurological disability with accompanying white matter lesion(s) on imaging, that may or may not develop into MS characterized by recurrent lesions distributed in space and time

doi: 10.1038/nature05760 116 ChristenSLorendeauDSchmiederRBroekaertDMetzgerKVeysKet al