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Moreover, not only oxidative and electrophilic reactions, but also other types of posttranslational modifications of Keap1, such as ubiquitination and phosphorylation, appear to be critical for regulating Nrf2 activity, which has been comprehensively discussed in a recent review ( Nrf2-Mediated Cardiac Protection Zhu et al

c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly (ADP-ribose) polymerase-1 activation

8-hydroxyguanine (8-OHG) activates the cGAS-STING-IRF3 axis, which significantly increases IFN- secretion and promotes M1 polarization

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Source: Emergency Physicians Fatigue: Feeling tired can happen, affecting around 11% of users