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Understanding the redox thresholds that affect EMT and mesenchymalepithelial transition (MET) is likely to reveal significant biochemical pathways that determine the metastatic potential of various tumor cell types

Cancer Science 108:21872194

For instance, an interesting study in Caenorhabditis elegans showed that an imbalance between mitochondrial- and nuclear-encoded proteins in neurons activates the mitochondrial unfolded protein response (UPR mt ) in intestinal cells, through an unidentified mi-tokine [18,19]

Similarly, improved antioxidant activity was detected for resveratrol loaded in lipidcyclodextrin-based nanoparticles compared to free resveratrol [58]

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