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Particularly notable is research demonstrating MOTS-cs influence on nuclear gene expression: the peptide has been shown to translocate to the nucleus under stress conditions and bind to AMPK-response elements, directly influencing the transcription of genes involved in stress resistance and metabolic adaptation

prausnitzii and SCFAs concentrations, thereby enhancing the drugs bioactivity and toxicity and further damaging the gut epithelial barrier leading to infiltration of other opportunistic pathogens (reviewed in Weersma et al., 2020)

This combination approach allows lower doses of each component, potentially reducing side effects while maintaining efficacy

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The capsule format supports convenient laboratory handling, consistent experimental preparation, and extended research workflows