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doi: 10.1111/all.15090

Hence, the overexpression of Hsa21 genes encoding proteins and non-coding RNAs (ncRNAs) could eventually disrupt several cellular functions and biological processes, thus giving rise to the different clinical conditions of DS (Antonarakis, 2017)

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No single finding or test result will confirm the presence or absence of this disease, but rather, accurate diagnosis lies with comparison against a pre-established set of criteria, as defined by the American Rheumatism Association