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Initially, it seemed improbable to screen over 3,000 analogs only to discover a compound operating through the well-established effector, CRBN, especially one with minimal independent affinity for the ligase

Doch gerade diese seelische Belastung kann zu einer weiteren Histaminfalle werden

In vitro experiments appear to explain this outcome, as they indicated that these oxidants react too slowly with typical protein thiols to constitute a threat during natural levels of stress

Therefore, the H 2 O 2 concentration for inducing oxidative stress was selected to be 500 M, which showed a survival rate of about 60% compared with the untreated control cells

The strategy of combining anti-DTP with anticancer therapy could be considered a promising approach