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16 Subsequent meta-analysis of 15 smaller RCTs with a total of 651 patients with DPN corroborated these results, emphasizing that the treatment with ALA (300-600 mg/day IV for 2-4 weeks) is safe and significantly improves neuropathic pain and nerve conduction velocity

It claims to have an effect in as little as two weeks and reviewers stand by this: "My legs look so much better," said one Amazon user

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Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats