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This extraordinary potency arises from the combination of the D-phenylalanine substitution at position 7, which confers enzymatic resistance and enhanced receptor binding geometry, the Nle substitution at position 4 that prevents methionine oxidation, and the cyclic lactam constraint that pre-organizes the pharmacophore into the bioactive conformation

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doi: 10.3390/biomedicines11020431, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 103

Extracellular superoxide dismutase deficiency and atherosclerosis in mice

suvi ekstrakt lista zelenog aja ( Camellia sinensis ), 16:1, standardizovan na 90% polifenola i 30% EGCG