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The stages of its initiation and development are outlined below and diagrammed in Figure 2

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GV-971, a sodium oligomannate, modulates gut microbiota amino acid metabolism to reduce the activation of T helper 1 cells, thereby inhibiting M1-type microglia activation, ultimately alleviating neuroinflammation and enhancing cognitive function in AD mice (165)

and involved with inflammatory responses, gene regulation, and apoptosis

In extreme cases, complications can lead to Stevens-Johnson syndrome or kidney failure