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PGC-1, peroxisome proliferator-activated receptor-gamma coactivator-1

What Is Glutathione, How It Works

Elevated glycolytic flux ensures the availability of glycolytic intermediates to initiate side-branches of glycolysis, such as the serine/glycine (ser/gly) synthesis pathway

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In this context, the increased extracellular glutamate can bind to its receptor, the metabotropic glutamate receptor 5 (mGluR5) on the stellate cell surface, stimulating it to synthesize 2-arachidonoylglycerol (2-AG) [155], which in turn, once released into the extracellular space, binds to the cannabinoid receptor-1 (CB1R) on hepatocytes, triggering a mechanism of de novo lipogenesis and therefore of fat accumulation [156] (Figure 7)