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Therefore, the methylation of NA is not only relevant to the abundance of free NAD + but is also relevant to the activity of these NAD + -consuming enzymes, because as a metabolite of these NAD + -consuming reactions, NA naturally has inhibitive effects on these enzymes

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But what is it that allows some people to recover within a couple of weeks while others suffer from long-term symptoms like severe fatigue, brain fog, and unpredictable heart rates for months or even years