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Results S2P f -eDHFR maintains membrane localization and specific [ 18 F]FP-TMP binding in cells To prevent cleavage and the uncoupling of the reporter protein (eDHFR) from the immunogenic species (S2P), the furin cleavage site was deleted from S2P and eDHFR was genetically fused to the C-terminus (S2P f -eDHFR) for PET imaging (Fig

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[DOI] [PubMed] [Google Scholar] 3.Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, et al

Because mitochondria are the primary site of ROS production, mitochondrial DNA(mtDNA) and the lipids and proteins that make up the mitochondrial matrix are vulnerable to damage from high levels of ROS (Amaral et al

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