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Some of these UFPs are further distributed in the systemic circulation, potentially penetrating the intact blood-brain barrier (BBB) in mice and reaching the brain tissue, resulting in the extrapulmonary effects of air pollution [3537]

The DHFR gene is located on chromosome 5q14.1 and is composed of 6 exons that generate three alternatively spliced mRNAs, each of which encode distinct protein isoforms

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Apamin suppresses vascular smooth muscle cell migration and growth in the vascular wall by targeting the Akt and Erk signaling pathways