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Given these facts, our findings may support the idea that giving LS and GSH, in their traditional and NP forms, either alone or in combination, can improve GN-induced ARF by reducing the protein expression of IL-6, TNF-, and caspase-3

[42] [43] Half-life is determined by clearance (CL) and volume of distribution (V D ) and the relationship is described by the following equation: In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed

doi: 10.1186/s13063-017-1972-x 75 KassimatisTGreenlawRHunterJPDouiriAFlachCRebollo-MesaIet al

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4.1 Epithelial barrier dysfunction: the initiation of axis activation The airway epithelium is the first line of defense against environmental triggers and the initial site of axis activation