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doi: 10.1096/fj.202000238RRR [DOI] [PubMed] [Google Scholar] 75

In a randomized controlled clinical study (102), 40 patients were treated with self-compatible Fuling (Smilax glabra Roxb.) total flavone decoction plus conventional treatment regimen, while the control group received a conventional treatment regimen only

After the 3 rd passage, cells appear to be stable in culture 29

Interestingly, both in vivo and in vitro studies have shown that the accumulation of -syn in the mitochondria of human DA neurons leads to decreased complex I activity, increased production of ROS, reduced substrate-specific respiration, and increased mitophagy [86, 87]

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