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141 The active form of this vitamin in patients with functional transcobalamin II and normal B 12 cell metabolism can inhibit production of this biomarker by indirect mechanisms, that is, through downregulation of NFB levels and increased acetylcholine synthesis, which positively modulates the neuro-immune cholinergic anti-inflammatory pathway

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The median relative abundance of Akkermansia increased from 0.01% to 32.48% ( P = 0.0079 ), and Oscillospira and Roseburia both slightly increased ( P = 0.0079 )