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Since most PK-deficient patients are compound heterozygous for two different mutations, rather than homozygous for one, several different tetrameric forms of PK-R may be present, each with distinct structural and kinetic properties

Tumor stemness: Tumor stemness represents the capacity for cancer cells to display self-renewal, differentiation, and tumor-initiation potential, identical to regular stem cells

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for instance, oxidative degradation of cellular lipids can suppress hepatitis C virus (HCV) replication [691]

(2) Preclinical-to-clinical translation: conducting phase I/II trials to validate efficacy, safety, and pharmacokinetic profiles of emerging platforms (e.g., artificial organelles and nanozymes)