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As demonstrated in apoE (/) and LDLR (/) mice, the polysaccharide CM1 can significantly decrease atherosclerotic plaque formation in the aorta of these mice

A prior study identified six putative phosphorylation sites (S155, T189, T216, S246, S284, T292) within ArfGAP1 by mass spectrometry yet no quantitative analysis was provided, and it was unclear which LRRK2 variants were used in these assays, including whether comparison to a kinase-inactive LRRK2 negative control was included (Xiong et al., 2012)

We find that the loss of GCLC across all tissues of adult animals results in rapid weight loss and death

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