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p=0.003) Discussion Since the first report of the neurotoxicity of the copper chelator cuprizone in Swiss albino mice by Carlton in 1966 (Carlton, 1966) and the subsequent early description of CPZ-induced OL death and demyelination in the superior cerebellar peduncles of ICI mice (Blakemore, 1972), the CPZ-induced demyelination model has been intensively studied and optimized for more than five decades (Vega-Riquer et al., 2019)

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Huang P, Wang F, Sah BK, Jiang J, Ni Z, Wang J, et al

A., Altered Expression of Intracellular TollLike Receptors in Peripheral Blood Mononuclear Cells from Patients With Alopecia Areata, BBA Clinical 5 (2016): 134142