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Despite the widespread use of levothyroxine replacement therapy, a substantial proportion of patients continue to experience persistent symptoms and metabolic dysregulation even after achieving biochemical euthyroidism

J Clin Endocrinol Metab 2003

While Lactobacillus plantarum generally enhances gut microbiota structure/function, improving health and lifespan in model organisms, the in vivo effects, mechanisms, and potential anti-aging properties of the SAL strain remain unexplored

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Studies show that oxidative stress and gut microbiota dysbiosis play crucial roles in the development and progression of aging and its related diseases (Tanriover et al., 2023