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However, the uncertainty with this is whether it presents a pre-vitamin B12 deficiency or PA, where individuals are not yet symptomatic or are symptomatic but have a serum B12 value within the normal reference ranges

A skin biopsy, measurement of metabolites (such as serum methyl malonic acid and homocysteine), and a Schilling test would have thrown more light on the diagnosis

Pregnancy Teratogenic Effects: Pregnancy Category C Adequate and well-controlled studies have not been done in pregnant women

Black or tarry stool, visible blood in the stool, vomiting blood, severe abdominal pain, unexplained weight loss, persistent fever, anemia, or progressive swallowing difficulty should be evaluated appropriately

Taken together, these data suggest that LA regulates tight junction assembly in leaky epithelia in part via a mechanism related to regulation of MLC phosphorylation