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A third line of antioxidant defense is the repair or removal of oxidized proteins and other biomolecules by a variety of enzyme systems, paradoxically induced by oxidants

N-acetylcysteine (NAC) shows promise in treating stress-related conditions like anxiety, depression, and PTSD by reducing oxidative stress and inflammation

We present six stories, discussing changes in sensitivity or resistance to azoles, cisplatin, oxidative stress, arginine biosynthesis perturbations, DNA synthesis inhibitors, and tamoxifen, to demonstrate the power of this novel methodology to broadly profile changes due to gene mutations

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