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The ACO2 gene is located on chromosome 22q13.2 and is composed of 18 exons that encode a precursor protein of 780 amino acids

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In B16F-10 melanoma-induced metastasis-bearing C57BL/6 mice, sulforaphane has been shown to enhance natural killer cell activity while also enhancing antibody-dependent cellular cytotoxicity in metastatic tumour-bearing animals [28]

10.1210/en.2006-1573 41 RothS.AbernathyM

The inhibition of the cystine/glutamate transporter hinders glutathione synthesis and induces ferroptosis, a regulated form of cell death characterized by excessive accumulation of lipid peroxides