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Skene PJ, Illingworth RS, Webb S, et al

Initially, it can increase heart rate and blood pressure, primarily due to its stimulating effects on the heart and its ability to increase catecholamine release

10.3390/nu15010048 274 LianH.YangL.ColeA.SunL.ChiangA

Combination Therapy (Alpha-Blocker + 5-ARI) (Example: Jalyn ) Benefit: Immediate symptom relief + long-term reduction in prostate size Best for: Men with moderate-to-severe symptoms and large prostates Data from MTOPS Trial: Combination therapy delayed progression more than either drug alone Risk of progression reduced by 66% with combination therapy Also led to greater improvement in symptom scores and lower need for surgery 4

These two receptors can, moreover, form heterodimers, which bind both ligands