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Enrichment of total ubiquitin chains was performed using TUBE2 agarose (LifeSensors, #UM402)
Apart from glutathione, another physiological reducing agent in the nucleus, thioredoxin-1 and other related systems also redistribute between nuclei and cytoplasm creating a protective reduced environment within the nucleus
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15 Rhopressa provides 4mm Hg to 5mm Hg IOP reduction in patients with high and low IOPs, which is great news, as it is inherently difficult to decrease low IOP
