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Description
In the key Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron 36 mg produced mean body weight reductions of 11.2% at 72 weeks in adults with obesity, with nearly 55% of participants achieving at least 10% weight loss and 36% achieving 15% or more
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These same studies also found improvements in mitochondrial function, metabolic markers, and reductions in oxidative stress and inflammation
This electron is subsequently channeled through three redox centers in MT-COX1
