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In these studies, the patients had severe symptoms ranging from chronic fatigue and pain to respiratory tracts diseases and hormone imbalances

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Consistent with the above content, a study showed that DMF is involved in protecting -amyloid-induced cytotoxicity and alleviating neurotoxicity by reducing the pro-inflammatory pathway: NF-B, as well as regulating the Nrf2 pathway to increase the production of antioxidant enzymes ( in vitro and in vivo, besides regulating antioxidant enzymes such as Nrf2, Mn-SOD, and HO-1, thereby reducing the levels of pro-inflammatory cytokines such as IL-1 and iNOS (Pan et al., 2018)

10.1007/s00401-003-0688-z 89