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In inflammatory bowel disease models, BPC-157 reduced the severity of experimentally induced colitis in rats when administered either intraperitoneally or intraluminally, suggesting activity through both systemic and local routes (Sikiric et al., 1993

The underlying logic is straightforward: if each component supports a different aspect of fat metabolism, combining all three could provide synergistic metabolic support

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And it enhances membrane permeability, potentially through interactions with cell surface receptors that recognize arginine-containing compounds