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Seminal fluid analyses of infertile males diagnosed with asthenozoospermia revealed diminished levels of vitamin C and elevated ROS levels compared to their fertile counterparts [97]

doi: 10.1089/ars.2015.6320

In type I Crigler-Najjar syndrome, a congenital missense mutation results in complete lack of this enzyme, whereas patients with type II Crigler-Najjar syndrome have a milder mutation that reduces UGT levels to about 10% of those seen in normal individuals

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All concentrations of acetaldehyde administered in the studies induced chronic tissue damage in the respiratory tract