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However, in clinical trials, the combination of gemcitabine with IGF-1R inhibitor received little overall survival benefits in advanced pancreatic cancer patients (Philip et al., 2014

doi: 10.1038/s41556-020-0481-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 89

Sulforaphane was found to prevent diabetes-induced hypertension and cardiac dysfunction in a study including hyperglycemic mice treated with or without sulforaphane (0.5 mg/kg daily for 5 days/week) for 3 months and with 3 months of further observation ( A number of observational studies have investigated associations between cruciferous vegetable intake and glucose metabolism and risk of type 2 diabetes

239,240 These hybrids have strong thermal stability and can activate RNase H degradation activity under specific conditions, indicating LNAs potential as an antisense drug

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