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The roles of mitochondrial dysfunction and reactive oxygen species in aging and senescence
A detailed workflow of this approach is shown in Figure 3B

Jiang S, Dong W, Zhang Z, Xu J, Li H, Zhang J, et al
Published mouse-to-human dose conversion factors typically apply factors of 12-15x reduction per kg

Stress induces reinstatement of drug-seeking behavior in animal models of drug consumption, exemplifying the link between reward and stress systems (221)