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Description
This has been reported as a major resistance mechanism against cDDP in several types of cancer [64, 65] and is believed to justify cell death when repairs are not possible [66]

Although several candidate drug resistance mechanisms, including impaired DNA repair, decreased drug uptake, increased drug efflux and detoxification, have been proposed (reviewed by Galluzzi et al, 2012), we are still some way from understanding the molecular basis of drug resistance, and from developing biomarkers to predict the onset and monitor the development of drug-resistant disease in cancer patients

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However, Nrf2 activation can exert dual effects

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